Bullous Pemphigoid vs Pemphigus Vulgaris

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Introduction

Bullous pemphigoid (BP) and pemphigus vulgaris (PV) are both autoimmune blistering diseases, but it is important to be able to differentiate between them to guide treatment and prognosis.

Bullous pemphigoid

Bullous pemphigoid typically presents in older adults with tense bullae. Nikolsky sign is negative.

Pemphigus vulgaris

Pemphigus vulgaris typically presents with flaccid blisters, and mucosal involvement is common. Nikolsky sign is positive.


Differentiating features

Bullous pemphigoid vs pemphigus vulgaris
Bullous pemphigoid vs pemphigus vulgaris Table 1. Comparison of bullous pemphigoid and pemphigus vulgaris1-4

References

  1. Ingold CJ, Sathe NC, Khan MAB. Pemphigus Vulgaris. StatPearls. Treasure Island (FL). 2024. Available from: [LINK].
  2. Ngan V, Oakley A, Shakel M. DermNet. Pemphigus vulgaris. 2022. Available from: [LINK]
  3. Baigrie D, Nookala V. Bullous Pemphigoid. StatPearls. Treasure Island (FL). 2023. Available from: [LINK].
  4. Oakley A, Coulson I. DermNet. Bullous pemphigoid. 2024. Available from: [LINK].

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