•Active infection, cellulitis, or dermatitis at the site of administration.
•Known allergy or hypersensitivity to the drug.
•Acute myocardial infarction- the release of muscle enzymes complicate the management strategy.
•Thrombocytopenia.
•Coagulation defects.
•Hypovolemic shock – the drug’s absorption may be hampered due to compromised vascularity of the muscle.
•Myopathies.
•Associated muscular atrophy – leads to delayed drug absorption and increases the risk of neurovascular complications.