Autonomic Pharmacology | Cholinergic Agonists

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In this lecture Professor Zach Murphy will be presenting on Cholinergic Agonists. We hope you enjoy this lecture and be sure to support us below!

Table of Contents:
0:00 Lab
0:07 Cholinergic Agonists Introduction
0:43 The Cholinergic System
11:11 Cholinergic Receptors and Agonists
32:56 Clinical Indications and Adverse Effects of Agonists
1:03:09 Cholinergic Agonists Practice Problems
1:16:32 Comment, Like, SUBSCRIBE!

Pharmacology Source:
Whalen, Karen. Lippincott Illustrated Reviews: Pharmacology (Lippincott Illustrated Reviews Series). Wolters Kluwer Health. Kindle Edition.

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Autonomic pharmacology refers to the study of drugs that affect the functions of the autonomic nervous system, which controls involuntary bodily functions such as heart rate, blood pressure, and digestion. One class of drugs that falls under this category is cholinergic agonists. Cholinergic agonists are drugs that mimic the effects of the neurotransmitter acetylcholine, which is released by cholinergic neurons in the body.

Cholinergic agonists can be classified into two main groups: muscarinic agonists and nicotinic agonists. Muscarinic agonists bind to muscarinic receptors in various body tissues, including the heart, lungs, and gastrointestinal tract. Nicotinic agonists, on the other hand, bind to nicotinic receptors in the skeletal muscles and autonomic ganglia.

Cholinergic agonists have a wide range of therapeutic applications. Muscarinic agonists can be used to treat conditions such as glaucoma, urinary retention, and gastrointestinal disorders such as irritable bowel syndrome. Nicotinic agonists, on the other hand, can be used as muscle relaxants in surgery or to treat conditions such as myasthenia gravis, a neuromuscular disorder.

However, cholinergic agonists can also have adverse effects. Overstimulation of the cholinergic system can lead to excessive salivation, sweating, and gastrointestinal motility, among other symptoms. Therefore, cholinergic agonists must be used with caution and under the guidance of a healthcare professional.

In summary, cholinergic agonists are drugs that mimic the effects of acetylcholine and have therapeutic applications in various body tissues. However, they must be used with caution due to their potential for adverse effects.


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