Autonomic Pharmacology | Adrenergic Antagonists

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In this lecture Professor Zach Murphy will be presenting on Adrenergic Antagonists within our short series on Autonomic Pharmacology. We hope you enjoy this lecture and be sure to support us below!

Table of Contents:
0:00 Lab
0:07 Adrenergic Antagonists Introduction
1:07 Adrenergic Neurons and Receptors
12:20 Adrenergic Target Organ Effects
24:47 Alpha 1 Antagonists
33:28 Alpha 1 + 2 Antagonists
49:48 Beta Antagonists
1:13:08 Beta 1 + 2 Antagonists
1:28:06 Beta + Alpha Blockers
1:40:30 Beta Blocker Overdose
1:47:30 Adrenergic Antagonists Practice Problems
1:58:54 Comment, Like, SUBSCRIBE!

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Pharmacology Source:
Whalen, Karen. Lippincott Illustrated Reviews: Pharmacology (Lippincott Illustrated Reviews Series). Wolters Kluwer Health. Kindle Edition.


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Autonomic pharmacology is a branch of pharmacology that deals with the study of drugs that affect the sympathetic and parasympathetic nervous systems. One of the most important classes of drugs used in this field is adrenergic antagonists. These drugs work by blocking the effects of the hormone adrenaline (also known as epinephrine) and noradrenaline (also known as norepinephrine) on the body’s adrenergic receptors.

Adrenergic antagonists are used to treat a variety of conditions such as hypertension, heart failure, angina, and arrhythmias. They can also be used to treat conditions such as pheochromocytoma, a rare tumor that can cause excessive production of adrenaline and noradrenaline.

There are several types of adrenergic antagonists, including alpha blockers, beta blockers, and alpha-beta blockers. Alpha blockers work by blocking the alpha-adrenergic receptors, which are found in the walls of blood vessels and in other tissues. This causes the blood vessels to relax, which can help lower blood pressure. Beta blockers work by blocking the beta-adrenergic receptors, which are found in the heart and in other tissues. This can help reduce the heart rate and the force of the heart’s contractions, which can help reduce blood pressure and improve heart function.

Adrenergic antagonists can have side effects, such as dizziness, fatigue, and gastrointestinal disturbances. They can also cause more serious side effects, such as hypotension, bradycardia, and bronchospasm. Patients taking adrenergic antagonists should be monitored closely for these side effects.

In conclusion, adrenergic antagonists are a vital class of drugs used in autonomic pharmacology. They are used to treat a variety of conditions such as hypertension and heart failure, and they work by blocking the effects of adrenaline and noradrenaline on the body’s adrenergic receptors. However, they can have side effects and patients taking these drugs should be monitored closely.


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