Brand name: Nesina
Uses: Alogliptin is used to treat type 2 diabetes (non-insulin-dependent diabetes) in adults. It helps to control blood sugar levels by reducing the amount of glucose produced by the liver.
Indications: Alogliptin is indicated for adults with type 2 diabetes to improve glycemic control when used in combination with other glucose-lowering medications, such as metformin, thiazolidinediones, and/or sulfonylureas.
Contraindications: Alogliptin should not be used in patients with type 1 diabetes, diabetic ketoacidosis, or with a history of pancreatitis. It should also not be used in patients with severe renal impairment or end-stage renal disease.
Drug Interactions: Alogliptin can interact with other medications, such as insulin and medications used to treat HIV. It is important to tell your doctor about all medications and supplements you are taking before starting alogliptin.
Mode of Action: Alogliptin works by inhibiting an enzyme called dipeptidyl peptidase-4 (DPP-4) which is involved in the breakdown of incretin hormones. By blocking this enzyme, alogliptin helps to increase the levels of incretin hormones which help to reduce glucose production by the liver and increase insulin secretion.
Side Effects: Common side effects of alogliptin include headaches, dizziness, nausea, diarrhea, and upper respiratory infections. Less common side effects include rash, itching, and swelling. In rare cases, alogliptin can cause serious and potentially life-threatening allergic reactions.